Zyp Czyk really outdid herself with this one…hard to imagine, but it’s true. Incredibly concise, clear statement of FACTS (remember those?).
Cohort Study of the Impact of High-Dose Opioid Analgesics on Overdose Mortality | Pain Medicine | Oxford Academic – January 2016
Objective.
Previous studies examining opioid dose and overdose risk provide limited granularity by milligram strength and instead rely on thresholds.
We quantify dose-dependent overdose.
Spoiler: there is no linear or incremental increase in overdose risk by dosage. The 90MME limit proposed by the CDC Guideline isn’t based on science, but more like a consensus “best guess” by addiction doctors.
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ecanarensis 